4'-Aminoacetanilide

CAS No.: 122-80-5

product details:

Purity: 99%

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  • Molecular Formula: C8H10N2O
  • Molecular Weight: 150.18
  • Appearance/Colour: pink to brown fine crystalline powder 
  • Vapor Pressure: 0.008mmHg at 25°C 
  • Melting Point: 164-167 °C(lit.) 
  • Refractive Index: 1.636 
  • Boiling Point: 267.726 °C at 760 mmHg 
  • PKA: 14.75±0.70(Predicted) 
  • Flash Point: 115.717 °C 
  • PSA: 55.12000 
  • Density: 1.203 g/cm3 
  • LogP: 1.88140 

4'-Aminoacetanilide(Cas 122-80-5) Usage

General Description

White or slightly reddish solid.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Hazard

Moderate toxicity by ingestion.

Fire Hazard

Flash point data are not available for 4'-Aminoacetanilide, but 4'-Aminoacetanilide is probably combustible.

Purification Methods

Crystallise the anilide from water. It has an unstable crystalline form with m 141o. It has IR: max (CCl4) 1681cm-1. [Beilstein 13 H 94, 13 I 28, 13 II 50, 13 III 166, 13 IV 137.]

InChI:InChI=1/C8H10N2O/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)

122-80-5 Relevant articles

A ternary Cu2O-Cu-CuO nanocomposite: A catalyst with intriguing activity

Sasmal, Anup Kumar,Dutta, Soumen,Pal, Tarasankar

, p. 3139 - 3150 (2016)

In this work, the syntheses of Cu2O as w...

Development of a continuous-flow system for catalysis with palladium(0) particles

Solodenko, Wladimir,Wen, Hongliang,Leue, Stefanie,Stuhlmann, Friedrich,Sourkouni-Argirusi, Georgia,Jas, Gerhard,Schoenfeld, Hagen,Kunz, Ulrich,Kirschning, Andreas

, p. 3601 - 3610 (2004)

Heterogeneous catalysis for organic synt...

Chemoselective reduction of nitroaromatics to anilines using decaborane in methanol

Bae, Jong Woo,Cho, Young Jin,Lee, Seung Hwan,Yoon, Cheol Min

, p. 175 - 177 (2000)

Nitrobenzenes were chemoselectively redu...

Efficient reductions of nitroarenes with SnCl2 in ionic liquid

De, Prithwiraj

, p. 1835 - 1837 (2004)

Mild, eco-friendly and fast reductions o...

Reduction of nitro-aryl compounds with zinc in the presence of poly[N-(2-aminoethyl)acrylamido]-trimethylammonium chloride as a phase-transfer catalyst

Mahdavi, Hossen,Tamami, Bahman

, p. 1121 - 1127 (2005)

The new polymeric phase-transfer catalys...

Thiazole ring-containing amide compounds as well as preparation method and application thereof

-

Paragraph 0044; 0048, (2021/06/23)

The invention discloses thiazole ring-co...

Selective Carbon-Carbon Bond Amination with Redox-Active Aminating Reagents: A Direct Approach to Anilines?

Qiu, Xu,Wang, Yachong,Su, Lingyu,Jin, Rui,Song, Song,Qin, Qixue,Li, Junhua,Zong, Baoning,Jiao, Ning

supporting information, p. 3011 - 3016 (2021/09/13)

Amines are among the most fundamental mo...

Synthesis of ring-opened derivatives of triazole-containing quinolinones and their antidepressant and anticonvulsant activities

Song, Ming-Xia,Huang, Yu-Shan,Zhou, Qiu-Gui,Deng, Xian-Qing,Yao, Xiao-Dong

, (2020/12/07)

Based on the potent antidepressant and a...

Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction

-

Paragraph 0111-0119, (2021/05/29)

The invention provides a ligand compound...

122-80-5 Process route

(4-acetylaminophenyl)carbamic acid tert-butyl ester
769121-30-4

(4-acetylaminophenyl)carbamic acid tert-butyl ester

N-acetyl-p-phenylenediamine
122-80-5

N-acetyl-p-phenylenediamine

Conditions
Conditions Yield
With hydrogenchloride; In dichloromethane; at 0 ℃; for 0.583333h;
65%
With trifluoroacetic acid;
In water; at 150 ℃; for 0.666667h; Green chemistry;
100 %Chromat.
With trifluoroacetic acid; In dichloromethane; at 0 - 25 ℃; for 16h; Inert atmosphere;
1.5 g
4-(+/-)-α-hydroxyethylphenylacetamide
16375-92-1

4-(+/-)-α-hydroxyethylphenylacetamide

N-acetyl-p-phenylenediamine
122-80-5

N-acetyl-p-phenylenediamine

Conditions
Conditions Yield
With O-pivaloylhydroxylamine trifluoromethanesulfonate salt; water; at 60 ℃; for 8h;
78%
With sodium azide; trifluoroacetic acid; In hexane; at 40 ℃; for 4h; Sealed tube;
76%
With sodium azide; methanesulfonic acid; trifluoroacetic acid; In hexane; at 40 ℃; for 12h;
76%

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    nicotinic acid-(4-acetylamino-anilide)

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